Fig. 2.
Attenuation of cardiac hypertrophy and dysfunction induced by ISO or AngII in CYP2J2 Tr mice. (A) CYP2J2 protein level was increased in CYP2J2 Tr mice compared with WT mice. (B) Urinary 14,15-DHET levels were increased in CYP2J2 Tr mice compared with WT mice (n = 10 per group). *P < 0.05 versus WT mice. (C and E) Representative gross appearance of hearts (left) from CYP2J2 Tr and WT mice treated with ISO or AngII, respectively. (D and F) The ratio of heart weight/body weight (HW/BW) of CYP2J2 Tr and WT mice treated with ISO or AngII, respectively (n = 5). *P < 0.05 versus WT mice treated with saline; #P<0.05 versus WT mice treated with ISO or AngII. Scale bar, 5 mm.