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Baseline visit Aβ1–42 (a), t-tau (b) and p-tau181 (c) CSF values (x-axis) against their yearly change (y-axis) during a follow-up of 36–48 months for cognitively normal subjects (CN in red), mild cognitive impairment subjects (MCI in green) subjects and Alzheimer’s disease (AD in blue) subjects. Open versus closed circles indicate the absence or presence of an APOE ε4 allele in each diagnostic group
