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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 2;62:10.1016/j.nbd.2013.09.018. doi: 10.1016/j.nbd.2013.09.018

Table 2.

Changes from control observed by the Butterfield group with regard to the HO/BVR-A system in AD and MCI subjects (Barone et al., 2011a; Barone et al., 2011b; Barone et al., 2012a; Calabrese et al., 2006; Di Domenico et al., 2012; Di Domenico et al., 2010)

Hippocampus Cerebellum IPL Plasma Lymphocyte
HO-1 protein levels MCI ≠ ≠ N/A Inline graphic 70%, * -
AD Inline graphic 119%, ** Inline graphic 38%, ns Inline graphic 400%,** Inline graphic 130%, * Inline graphic 150%, **,%
HO-1 oxidation MCI Inline graphic HNE 85%, * Inline graphic HNE 36%, * - - -
AD Inline graphic PC 30%, ** Inline graphic PC 32%, * - - -
Inline graphic HNE 52%, *
HO-1 phosphorylation MCI ≠ Inline graphic pSer 24%, * - - -
AD Inline graphic pSer 26%, * Inline graphic pSer 21%, * - - -
HO-2 protein levels MCI Inline graphic 32%, * ≠ Inline graphic 270%, ** - -
AD Inline graphic 32%, * ≠ - - -
BVR-A protein levels MCI Inline graphic 44%, * ≠ - Inline graphic 10%, ns -
AD Inline graphic 45%, ** ≠ - Inline graphic 36%, * -
BVR-A oxidation MCI Inline graphic 3-NT 30%, ** ≠ - Inline graphic 3-NT 24%, * -
AD Inline graphic 3-NT 95%, ** ≠ - Inline graphic 3-NT 44%, * -
BVR-A phosphorylation MCI Inline graphic pTyr 20%, * ≠ Inline graphic pTyr 22%, *
Inline graphic pSer/Thr 40%, ** - -
AD Inline graphic pTyr 40%, ** ≠ Inline graphic pTyr 57%, *
Inline graphic pSer/Thr 28%, ** - -
BVR activity MCI Inline graphic 40%, ** ≠ - ≠ -
AD Inline graphic 27%, ** ≠ - Inline graphic 30%, * -

Inline graphic Increase, Inline graphic decrease, ≠ no changes,

*

p<0.05,

**

p<0.01,

ns non significant, N/A not applicable, IPL Inferior Parietal Lobule,

%

Corresponding author: V. Calabrese.