Figure 2. AD LCLs demonstrate differences in mitochondrial function as compared to control LCLs at baseline and after exposure to DMNQ.
(A) ATP-linked respiration and (B) proton leak respiration were overall significantly higher in the AD LCLs, and there was a greater increase in proton leak respiration with DMNQ as compared to control LCLs. (C) Maximal respiratory capacity was significantly elevated in the AD LCLs at 0 µM and 5 µM DMNQ compared to control LCLs, and the AD LCLs exhibited a greater decrease in maximal capacity as DMNQ increased as compared to control LCLs. (D) Reserve capacity was significantly elevated in the AD LCLs at baseline, and it decreased with DMNQ so that it was significantly lower than control LCLs at 10–15 µM DMNQ. *p<0.001; **p<0.0001; ↕ indicates an overall statistical difference between LCL groups.