Figure 2.
Superior performance of conditional Cdk5 KO mice in contextual fear conditioning, extinction and water-maze reversal learning and memory tasks. (a,b) Context- and cue-elicited memory 24 h after training and extinction. Freezing times before conditioning (Pre) and after context (n = 20) or cue (n = 11–12) re-exposure are shown with extinction learning to contextual environment (n = 10). (c,d) Learning and memory in water maze. Escape latencies of training and reversal (four trials per day) are shown with visual acuity assessment (V), and individual trials 1–8 on reversal days 1–2 (left). Spatial preferences and representative paths after initial and reversal training are shown as the percentage of time spent in target quadrant (T, right). L, O and R indicate left, opposite and right quadrants, respectively; n = 10–11. Data represent mean ± s.e.m.; *P < 0.05 post hoc, ***P < 0.01 versus WT, **P < 0.05 versus other quadrants, †P < 0.05 versus WT in T; Student’s t-test.