Table 1.
Functional neuroimaging of amygdala activation in experimental pain studies
| Paper | Method | Subjects | Stimulation | Site | Foci | Smoothing | Signal |
|---|---|---|---|---|---|---|---|
| Baliki et al., 2009 | 3T fMRI | 14 (7F) | Thermode | Back | 2(B) | 5mm | In |
| Becerra et al., 1999 | 1.5T fMRI | 12M | Thermode | L hand | 2 (B)a | NR | D |
| Berman et al., 2008 | 1.5T fMRI | 12F | Rectal distention | Rectum | 1 (right) | 5mm | D |
| Bingel et al., 2002 | 1.5T fMRI | 14(1F) | Laser | R/L hand alternating | 2 (B) | 6mm | In |
| Bingel et al., 2006 | 1.5T fMRI | 19 (4F) | Laser | R/L hand alternating | 2 (B) | 8mm | In |
| Bornhovd et al., 2002 | 1.5T fMRI | 9(3F) | Laser | L hand | 2 (B) | 6mm | In |
| Carlsson et al., 2006 | 1.5T fMRI | 9(5F) | Electric shock | R wrist | 1 (C) | 12mm | In |
| Derbyshire et al., 1997 | PET | 12(6F) | Laser | R hand | 2 (B) | 10mm | D |
| Dimitrova et al., 2003 | 1.5T fMRI | 16(5f) | Electric | L tibial nerve | NR | 6mm | In |
| Dube et al., 2009 | 1.5T fMRI | 9(3F) | Thermode | L leg | 1 (I) | 8mm | In |
| Iadarola et al., 1998 | PET | 13(5F) | mechanical allodynia post capsaicin injection | L volar forearm | 1 (I) | NR | In |
| Kulkarni et al., 2005 | PET | 17M | Laser | L dorsal forearm | 1 (C) | 16mm | In |
| Kupers et al., 2004 | PET | 10 (4F) | 5% solution of hypertonic saline | R masseter muscle | 1 (I) | 12mm | D |
| Lu et al., 2004 | 3T fMRI | 10(2F) | Gastric pain via balloon | Abdomen | 1 (right) | 8mm | In |
| Mainero et al., 2007 | 3T fMRI | 12M | mechanical allodynia post capsaicin injection | R Trigeminal nerve | 2 (B) | 4mm | In |
| Mobascher et al., 2009 | 3T fMRI | 20M | Laser | L hand | 1(C) | 6mm | In |
| Mohr et al., 2005 | 1.5T fMRI | 16M | Thermode | R hand | 1 (I) | 8mm | In |
| Petrovic et al., 2004 | PET | 10M | Cold pressor (1‐glycol; 1‐ice) | L hand | 2 (B) | 10mm | D |
| Peyron et al., 2007 | 1T fMRI | 9M | Electric | L leg | 1 (C) | 10mm | In |
| Schneider et al., 2001 | 1.5T fMRI | 6M | Vascular pain via balloon | Dorsal vein L foot | 1 (C) | 6mm | In |
| Seminowicz and Davis, 2006 | 1.5T fMRI | 22 (12F) | TENS | Left median nerve | 1 (C) | 6mm | In |
| Takahashi et al., 2011 | 3T fMRI | 13M | Electrical stimulation | L Tibial muscle | 2 (B) | 8mm | In |
| Yoshino et al., 2010 | 1.5T fMRI | 15(6F) | Electric intraepidermal | L forearm | 1 (C) | 8mm | In |
a
Did not report foci coordinates.
B = bilateral, C = contralateral to stimuli, D =decreased signal, I = ipsilateral to stimuli, In=increased signal; NR = not reported.