Table 2.
Main modifications of lymphocytes subpopulations between Alzheimer’s disease patients and age-matched controls
| Phenotype | Lymphocyte subpopulation | Changesin Alzheimer disease | Reference |
|---|---|---|---|
| CD19+ |
Total B cells |
Decrease |
[82] |
| (percentage) |
|
|
[83] |
| |
|
|
[63] |
| CD19+ |
Total B cells |
Decrease |
[82] |
| (absolute number) |
|
|
[63] |
| CD3+ |
Total T cells |
No change |
[63] |
| (percentage) |
|
Decrease |
[81] |
| |
|
|
[83] |
| |
|
|
|
| CD3+CD8+(percentage) |
Cytotoxic T lymphocytes |
No change |
[63] |
| |
|
|
[83] |
| |
|
Decrease |
[81] |
| CD3+CD4+ |
T-helper cells |
No change |
[63] |
| (percentage) |
|
|
[83] |
| |
|
Increase |
[81] |
| CD3+CD4+CD45RA+CCR7+ |
Naïve CD4+ T |
Decrease |
[79] |
| (percentage) |
cells |
|
|
| CD3+CD4+CD28+CD27+CD45RA+CD45RO- |
Naïve CD4+ T |
Decrease |
[75] |
| (percentage) |
cells |
|
|
| CD3+CD4+CD45RA-CCR7- |
Effector memory |
Increase |
[79] |
| (percentage) |
CD4+ T cells |
|
|
| CD3+CD4+CD45RA+CCR7-(percentage) |
Terminal effector memory RA cells |
Increase |
[79] |
| |
|
|
|
| CD3+CD4+CD28-CD27-CD45RA+CD45RO+ |
Late differentiated |
Increase |
[75] |
| (percentage) |
CD4+ T cells |
|
|
| CD3+CD4+CD25high |
Activated CD4+ T |
Decrease |
[79] |
| (percentage) |
cells |
|
|
| CD3+CD4+CD25+FoxP3+CD127low(percentage) |
Regulatory T cells |
No change |
[75] |
| CD3+CD4+KLRG-1+(percentage) | Senescent CD4+ T cells | Increase | [75] |