Figure 2.
Linkage and Haplotype Anlayses of Affected Individuals from Families A–F
(A) The contribution of each family to the combined hLOD score peak on chromosome 19. LOD scores of individual families were plotted in black, red, green, blue, orange, and dark aqua, respectively. The combined hLOD score was plotted in purple.
(B) Haplotypes for each affected individuals in the region under the chromosome 19 linkage peak. “1” and “2” are arbitrary labels to indicate the two different alleles of each SNP. Different colors indicate alleles inherited from different ancestors. Some markers used for linkage analysis are not displayed for conciseness. All affected individuals were homozygous by state from 23.14 to 26.89 cM (red box) and shared identical homozygous alleles from 23.14 to 25.05 cM (shaded in gray).