Table 1.
HLA-A*, -B*, and -C* allele frequencies in autistic children and controls.
| HLA | Autism | Controls | Statistical analysis | |
|---|---|---|---|---|
| 2n = 70 N (%) | 2n = 200 N (%) | OR (95% CI) | P | |
| A*01 | 12 (17.6) | 15 (7.50) | 2.68 (1.08–6.42) | 0.03 |
| A*02 | 30 (42.8) | 54 (27.00) | 3.02 (1.56–5.83) | 0.001 |
| A*11 | 2 (2.9) | 7 (3.50) | 0.83 (0.11–4.54) | 1.00 |
| A*23 | 2 (2.9) | 12 (6.00) | 0.47 (0.07–2.3) | 0.51 |
| A*26 | 6 (8.8) | 10 (5.00) | 1.8 (0.56–5.71) | 0.34 |
| A*29 | 2 (2.9) | 4 (2.00) | 1.48 (0.18–9.71) | 1.00 |
| A*31 | 8 (11.8) | 12 (6.00) | 2.1 (0.73–5.81) | 0.19 |
| A*32 | 2 (2.9) | 10 (5.00) | 0.51 (0.08–2.9) | 0.71 |
| A*33 | 4 (5.9) | 8 (4.00) | 1.5 (0.36–5.7) | 0.75 |
| A*68 | 4 (5.9) | 20 (10.00) | 0.56 (0.15–1.83) | 0.43 |
| B*07 | 10 (14.7) | 10 (5.00) | 3.27 (1.19–9.03) | 0.01 |
| B*08 | 4 (5.90) | 12 (6.00) | 0.97 (0.25–3.4) | 1.00 |
| B*14 | 4 (5.90) | 3 (1.50) | 4.1 (0.75–28.31) | 0.12 |
| B*15 | 4 (5.90) | 12 (6.00) | 0.97 (0.25–3.43) | 1.00 |
| B*18 | 4 (5.90) | 7 (3.50) | 1.73 (0.4–6.8) | 0.60 |
| B*35 | 2 (2.90) | 16 (8.00) | 0.34 (0.05–1.6) | 0.24 |
| B*40 | 2 (2.90) | 3 (1.50) | 1.94 (0.22–15.0) | 0.81 |
| B*41 | 4 (5.90) | 9 (4.50) | 1.32 (0.33–4.9) | 0.85 |
| B*44 | 2 (2.90) | 4 (2.00) | 1.48 (0.18–9.7) | 1.00 |
| B*50 | 8 (11.80) | 28 (14.00) | 0.82 (0.32–2.1) | 0.79 |
| B*51 | 16 (23.50) | 42 (21.00) | 1.15 (0.57–2.3) | 0.78 |
| B*52 | 4 (5.90) | 6 (3.00) | 2.01 (0.46–8.4) | 0.47 |
| B*57 | 2 (2.90) | 3 (1.50) | 2.01 (0.46–8.1) | 0.47 |
| B*58 | 2 (2.90) | 7 (3.50) | 0.85 (0.11–4.5) | 1.00 |
| C*01 | 2 (2.90) | 4 (2.00) | 1.48 (0.18–9.7) | 1.00 |
| C*04 | 4 (5.90) | 25 (12.50) | 0.43 (0.12–1.3) | 0.19 |
| C*05 | 2 (2.90) | 2 (1.00) | 3.0 (0.29–30.5) | 0.57 |
| C*06 | 12 (17.60) | 31 (15.50) | 1.16 (0.52–2.56) | 0.82 |
| C*07 | 12 (17.60) | 43 (21.50) | 0.78 (0.36–1.66) | 0.61 |
| C*08 | 4 (5.90) | 4 (2.00) | 3.1 (0.62–15.0) | 0.22 |
| C*12 | 6 (8.80) | 16 (8.00) | 1.11 (0.37–3.2) | 1.00 |
| C*15 | 16 (23.50) | 32 (16.00) | 1.6 (0.77–3.3) | 0.22 |
| C*16 | 4 (5.90) | 10 (5.00) | 1.1 (0.32–4.3) | 1.00 |
| C*17 | 6 (8.80) | 10 (5.00) | 1.84 (0.57–5.7) | 0.33 |
AF: allele frequency; OR: odds ratio; 95% CI: confidence interval; NS: not significant. 2n: each individual was represented by two codominant allelic data. The bold font in table refers to significant association of alleles and haplotype with autism.