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. 2014 Feb 26;5(1):68–74. doi: 10.4331/wjbc.v5.i1.68

Figure 4.

Figure 4

Activity profile of mouse ribonucleotide reductase in the presence of the thioredoxin and glutaredoxins system. Mouse R1 (120 μg/mL) and R2 (40 μg/mL) were assayed with dithiothreitol, thioredoxin (Trx) and glutaredoxin (Grx) systems. The Trx system contained 3.6 μmol/L Trx1, NADPH and TrxR. The Grx system contained 1 μmol/L Grx1, 4 mmol/L glutathione , NADPH and glutathione reductase. Combinations of 3.6 μmol/L Trx1 or the whole Trx system with the Grx system were also monitored (data adapted from Zahedi Avval et al[26]).