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. Author manuscript; available in PMC: 2014 Mar 9.
Published in final edited form as: Science. 2013 Oct 4;342(6154):1235587. doi: 10.1126/science.1235587

Fig. 3. SNPs in protein-protein interaction (PPI) network.

Fig. 3

(A) Degree centrality of coding-gene categories in PPI network. (B) Fraction of rare missense SNPs at protein-interaction interfaces is higher than all rare missense SNPs (error bars show 95% binomial confidence intervals; total number of SNPs also shown). (C) Effects of SNVs at interaction interfaces on interactions of WASP with other proteins tested by Y2H experiments. Wild-type (WT) WASP interacts with all proteins shown, whereas each missense SNV disrupts its interaction with at least one protein.