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Findings of selective dopamine (DA) and PPN cholinergic (ACh) lesions in rhesus monkeys. Data extracted from Karachi et al. [87].
| Nigral DA cells | PPN ACh cells | Postural deficits | |
|---|---|---|---|
| Isolated MPTP lesion young monkey | ↓↓ DA (~90%) | normal | No |
| Isolated MPTP lesion old monkey | ↓↓ DA (~90%) | ↓ ACh (~30%) | Yes |
| Isolated PPN lesion | Normal | ↓ ACh (~30%) | Yes |
