Table 2.
Metabolic pathways enriched in PR+ breast tumors. GSEA of microarrays from human breast tumors (585 tumors from postmenopausal women). KEGG-defined pathways that were enriched(p <0.05) or tended to be enriched(p <0.1) in PR+ tumors vs. PR− tumors, are shown.
| KEGG-defined Pathway | Normalized Enrichment Score | Nominal p-value | Significant in PR+ tumors from all ages | Functional Role |
|---|---|---|---|---|
| Ribosome | 2.60 | 0 | * | Protein Metabolism |
| Butanoate Metabolism | 1.88 | 0 | * | Carbohydrate Metabolism |
| Valine Leucine and Isoleucine Degradation | 1.77 | 0 | * | Protein Metabolism |
| Oxidative Phosphorylation | 1.75 | 0 | ATP Production | |
| Parkinsons Disease | 1.64 | 0 | Oxidative Phosphorylation and Mitochondrial Genes | |
| TGF Beta Signaling Pathway | 1.61 | 0 | * | Cell Growth |
| Glycosylphosphatidylinositol GPI Anchor Biosynthesis | 1.68 | 0.008 | * | Carbohyrdate Metabolism (Glycoloysis and Pentose Phosphate Shunt) |
| Propanoate Metabolism | 1.63 | 0.009 | * | Carbohydrate Metabolism |
| Alzheimers Disease | 1.38 | 0.009 | Mitochondrial Genes | |
| Porphyrin and Chlorophyll Metabolism | 1.68 | 0.020 | Heme Synthesis (Electron Carriers for Oxidative Phosphorylation) | |
| ECM Receptor Interaction | 1.45 | 0.026 | * | Metastatic Potential |
| Purine Metabolism | 1.38 | 0.027 | Nucleotide Metabolism | |
| Valine Leucine and Isoleucine Biosynthesis | 1.53 | 0.034 | * | Protein Metabolism |
| Nitrogen Metabolism | 1.45 | 0.053 | * | Protein Metabolism |
| Circadian Rhythm Mammal | 1.54 | 0.056 | Cell Proliferation | |
| Pentose and Glucuronate Interconversions | 1.47 | 0.064 | * | Carbohydrate Metabolism |
| Drug Metabolism Cytochrome P450 | 1.33 | 0.066 | * | Related to Tamoxifen Metabolism |
| Beta Alanine Metabolism | 1.46 | 0.067 | * | Protein Metabolism |
| Peroxisome | 1.30 | 0.068 | * | Membrane Protein Import; Fatty Acid Oxidation; Phospholipid Biosynthesis |
| Pyruvate Metabolism | 1.35 | 0.069 | * | Gluconeogenesis |
| Nucleotide Excision Repair | 1.32 | 0.083 | Nucleotide Metabolism | |
| Ascorbate and Aldarate Metabolism | 1.42 | 0.091 | * | Carbohydrate Metabolism |