. Author manuscript; available in PMC: 2014 Jun 1.

Published in final edited form as: Pharmacogenomics J. 2013 Sep 10;14(3):223–228. doi: 10.1038/tpj.2013.34

Table 1.

Contributions of individual variables identified from the derivation cohort (N=349) to the novel African American warfarin dose algorithm.

Coefficients	β	SE	P
Intercept	5.906	0.262	< 2e-16
Age^†	−0.015	0.002	1.36E-10
Weight^†	0.005	0.001	0.0005
DVT/PE	0.158	0.071	0.0265
^* CYP2C9 Star Variant CYP2C9^2^†, ^3^†, ^5, ^8, and ^*11	−0.254	0.086	0.0035
VKORC1 -1639 A>G^†	−0.370	0.081	8.70E-06
VKORC1 -8191 A>G	−0.097	0.032	0.0024
CYP2C9, rs7089580 A>T	0.060	0.040	0.1309
rs12777823 A>G	0.104	0.059	0.0794

SE = standard error

Variants were combined into a single group

The model predicts the log2 (dose) in mg/week.

^†

Shared variables between algorithms.