Figure 7. Proposed model for the interplay of lncRNAs, JARID2, and PRC2.
(A) At some target genes, the presence of JARID2 by itself (I) is not sufficient for maximum PRC2 recruitment, which requires scaffolding by lncRNAs (II). The presence of both JARID2 and lncRNAs stimulates further recruitment and assembly of PRC2 on chromatin, resulting in increased H3K27me3 (III). The structure of lncRNAs bound to JARID2 (and PRC2) remains to be elucidated and the one shown here is only for the purpose of illustration.
(B) In some cases, lncRNAs might contribute to the initial recruitment of JARID2 to chromatin (I). Because JARID2 also binds PRC2 via protein–protein interactions, this results in increased PRC2 recruitment and H3K27 methylation (II).