. 2012 Nov 14;3(4):799–838. doi: 10.3390/jfb3040799

Table 3.

Merits and demerits of electrospinning and bioplotter fabrication techniques for design-based scaffold fabrication.

Merits and demerits	Electrospinning	Bioplotter-additive manufacturing
Merits	Fine fibers (25–100 µm), ECM-like structure (good for cellular activities) [34,106] Use of minimum amount of material [202], minimizing material–cell/tissue interaction [171] Potential biofabrication capacity [106,203] Capable of incorporating multiple polymers [204,205]	Reproducible fabrication [69,209] Computer controlled Building of designed, specified structures; patient-specific grafts [169,209] Processing the widest range of biomaterials: hydrogels to polymer melts and hard substances [85,196] Design-based biofabrication capacity [195]
Demerits	Densely packed structure, small pore size, nonuniform cell infiltration/tissue formation [206,207] Need of postfabrication process, e.g., direct perfusion [105] and dynamic culturing [173,208] Limited design-based architectural/properties	Limited at high spatial resolution [69,192]