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Role of Bim in organoid death. Crypts from wild-type (wt) or Bim-deficient (Bim−/−) mice were isolated and cultured in Matrigel for 72 h. Organoids were treated overnight with different concentrations of TNFα (a) or cisplatin (b), and organoid death was determined by MTT assay. Mean values of three independent experiments ±S.D. are shown. All experiments were done in triplicates. *P<0.05 wt versus Bim−/−; **P<0.01 wt versus Bim−/−
