Table 1.
Clinical Characteristics by Cognitive Complaint Category
| Cognitively Normal
Participants | ||||||
|---|---|---|---|---|---|---|
| No Complaint n=3300 | Self Complaint n=656 | Informant Complaint n=139 | Self + Informant Complaint n=319 | p value | Total n=4414 | |
| Age, mean (SD), y | 72.6 (8.2) | 72.7 (8.4) | 73.9 (8.4) | 72.8 (7.4) | 0.35 | 72.7 (8.1) |
| Sex (% Female) | 70 | 70 | 57 | 56 | <0.001§,#**,†† | 69 |
| Race (% White) | 80 | 77 | 87 | 81 | 0.015 | 80 |
| Education, mean (SD), y | 15.8 (5.7) | 16.0 (7.2) | 15.1 (3.4) | 15.9 (8.8) | 0.09 | 15.8 (6.1) |
| Baseline MMSE score†, mean (SD) | 29.0 (1.4) | 28.9 (1.4) | 28.6 (1.7) | 28.5 (1.6) | <0.001§,¶,#,** | 28.9 (1.4) |
| Follow-up Period‡, mean (SD), y | 3.6 (1.8) | 3.3 (1.7) | 3.4 (1.7) | 3.2 (1.7) | <0.001§ | 3.5 (1.8) |
| Conversion Status Frequency | ||||||
| Stable/Persistent (%) | 91 | 83 | 80 | 71 | --- | 88 |
| Progressive/Converters (%) | 9 | 17 | 20 | 29 | --- | 12 |
| Mild Cognitive Impairment Participants | ||||||
|
| ||||||
| No Complaint n=263 | Self Complaint n=197 | Informant Complaint n=151 | Self + Informant Complaint n=1232 | p value | Total n=1843 | |
|
| ||||||
| Age, mean (SD), y | 74.3 (7.2) | 74.4 (7.9) | 76.3 (7.1) | 74.2 (7.5) | 0.02 | 74.4 (7.5) |
| Sex (% Female) | 57 | 64 | 45 | 50 | <0.001**,†† | 52 |
| Race (% White) | 68 | 67 | 80 | 85 | <0.001‡‡,§§ | 81 |
| Education, mean (SD), y | 15.8 (9.6) | 15.0 (3.4) | 15.3 (3.2) | 15.8 (5.7) | 0.04 | 15.6 (6.1) |
| Baseline MMSE score†, mean (SD) | 28.0 (1.8) | 27.5 (1.8) | 27.6 (1.9) | 27.3 (1.9) | <0.001§,¶ | 27.4 (1.9) |
| Follow-up Period‡, mean (SD), y | 3.1 (1.7) | 3.0 (1.8) | 3.2 (1.6) | 2.9 (1.6) | 0.21 | 3.0 (1.6) |
| Conversion Status Frequency | ||||||
| Reverters (%) | 32 | 25 | 8 | 6 | --- | 12 |
| Stable/Persistent (%) | 51 | 55 | 50 | 45 | --- | 47 |
| Progressive/Converters (%) | 17 | 20 | 42 | 49 | --- | 41 |
Note: Complaint categories are mutually exclusive and defined based on clinician-facilitated interviews with the participant and informant. MMSE=Mini Mental State Examination,
†
MMSE score range from 0–30 with lower score=worse performance;
‡
Follow-up period is time from the first visit until time to the last visit; Post-hoc group comparisons with Bonferroni correction:
§
no complaint > both complaints;
¶
no complaint > self complaint;
#
no complaint > informant complaint;
**
self complaint > informant complaint;
††
self complaint > both complaints;
‡‡
no complaint < both complaints;
§§
self complaint < both complaints