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. 2014 Jun 30;211(7):1289–1296. doi: 10.1084/jem.20132459

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© 2014 Min-Oo et al.

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Figure 1. — Bcl2l11^−/− Ly49H⁺ NK cells expand normally but demonstrate impaired contraction. (A) Levels of Bim mRNA are shown as relative levels for Ly49H⁺ NK cells after MCMV infection. (B) Plots show ratios of Bcl2l11^−/− and WT Ly49H⁺ cells in the spleen of mixed BM chimeric mice after MCMV infection (days 0, 7, and 21) of representative mice. (C) Absolute numbers of the WT and Bcl2l11^−/− KLRG1⁺Ly6C^hiLy49H⁺ cells are plotted. (D) Adoptively transferred Bcl2l11^−/− (CD45.2) and WT (CD45.1) Ly49H⁺ NK cells in peripheral blood were analyzed at days 1.5, 5, 7, 14, 21, and 28 after MCMV and are expressed as a percentage of NK1.1⁺TCRβ⁻ NK cells. (E) Tissue lymphocytes were analyzed at days 7, 21, and 28; graph shows Bcl2l11^−/− and WT Ly49H⁺ cells expressed as a percentage of NK1.1⁺TCRβ⁻ NK cells. For all panels, n = 3 mice per time point, and data are representative of two to three independent experiments. Error bars signify the standard error of the mean. ***, P < 0.0005; **, P < 0.005; *, P < 0.05 (paired Student’s t test).