Figure 4.
Functional classification scheme of IDRs. The function of disordered regions can stem directly from their highly flexible nature, when they fulfill entropic chain functions (such as linkers and spacers, indicated in dark-tone red), or from their ability to bind to partner molecules (proteins, other macromolecules, or small molecules). In the latter case, they bind either transiently as display sites of post-translational modifications or as chaperones (indicated in green), or they bind permanently as effectors, assemblers, or scavengers (indicated in dark-tone blue). More extensive descriptions and examples are found in the main text. Adapted with permission from ref (58). Copyright 2005 Elsevier.