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. Author manuscript; available in PMC: 2015 May 23.
Published in final edited form as: Vaccine. 2014 Apr 5;32(25):2948–2957. doi: 10.1016/j.vaccine.2014.03.078

Figure 1. Vaccination reduces the incidence of infectious disease.

Figure 1

Values represent the number of annual cases of disease that occurred in the United States during the pre-vaccine era (adapted from [2]) compared to the number of cases for each disease reported to the CDC in 2012 [3]. Invasive pneumococcal disease (IPD, Streptococcus pneumoniae) and Haemophilus influenzae type b (Hib) case numbers refer to children <5 years of age. Case numbers for polio include both paralytic and non-paralytic forms of the disease. For varicella, the reported incidence in 2012 was 11,477 cases, but this is likely to be underreported due to challenges in clinical diagnosis of milder vaccine-modified cases [92]. For diseases with an incidence of ≤10 cases in 2012, the number of total cases is indicated in parentheses.