Table 1.
Demographics and clinical features on initial visit. P value denotes statistical difference between MSA-C and MSA-P. Statistically significant P values are denoted in bold. Values are presented as means ± standard deviation where appropriate.
| MSA | MSA-C | MSA-P | P value | |
|---|---|---|---|---|
| DEMOGRAPHICS | ||||
| Patients, n | 100 | 40 | 60 | |
| Male: female | 61:39 | 65:35 | 58:42 | 0.21 |
| Age at first symptom (y) | 56±9 | 56±8 | 56±10 | 0.95 |
| Duration of disease before initial visit (y) | 5±3 | 5±2 | 5±3 | 0.69 |
| PRESENTING FEATURES | ||||
| Autonomic (%) | 48 | 54 | 43 | 0.32 |
| Motor (%) | 34 | 29 | 38 | 0.37 |
| Combined (%) | 18 | 17 | 19 | 0.84 |
| CLINICAL CHARACTERISTICS | ||||
| Neurological | ||||
| Bradykinesia (%) | 72 | 45 | 90 | <0.001 |
| Rigidity (%) | 67 | 28 | 93 | <0.001 |
| Postural instability (%) | 51 | 40 | 58 | <0.01 |
| Tremor (%) | 41 | 18 | 57 | <0.001 |
| Gait Ataxia (%) | 48 | 73 | 32 | <0.001 |
| Limb Ataxia (%) | 45 | 75 | 25 | <0.001 |
| Dysarthria (%) | 47 | 75 | 28 | <0.001 |
| Nystagmus (%) | 19 | 43 | 3 | <0.001 |
| Babinski sign (%) | 39 | 43 | 37 | 0.39 |
| Hyperreflexia (%) | 49 | 48 | 50 | 0.78 |
| UMSARS (units) | (n=30) 38.3±14 |
(n=15) 36.8±13 |
(n=15) 38.7±15 |
0.57 |
| Part I | 18.5±6 | 17.4±6 | 19.5±7 | 0.39 |
| Part II | 20.0±7 | 19.4±8 | 20.7±8 | 0.23 |
| L-dopa equivalent dose (mg) | (n=45) 426.6±290.2 |
(n=14) 528.5±284 |
(n=31) 380.6±285.6 |
0.12 |
| L-dopa response (%) | 31 | 8 | 39 | 0.07 |
| Autonomic | ||||
| Total SCOPA (units) | (n=36) 17.9±7 |
(n=18) 16.8±8 |
(n=18) 18.1±7 |
0.31 |
| Gastrointestinal | 4.2±3 | 3.9±3 | 4.5±3 | 0.46 |
| Urinary | 8.8±4 | 8.3±5 | 9.2±4 | 0.51 |
| Cardiovascular | 1.9±2 | 1.7±2 | 2.2±2 | 0.36 |
| Thermoregulatory | 1.6±2 | 1.4±2 | 1.7±2 | 0.58 |
| Pupillomotor | 0.4±1 | 0.4±1 | 0.4±1 | 0.94 |
| Sexual dysfunction | 1.6±1 | 1.5±1 | 1.8±1 | 0.31 |
| Fall in SBP after 3 min tilt (mmHg) | 38±29 | 34±20 | 40±34 | 0.34 |
| Frequency of OH (30/15 mmHg, %) | 69 | 69 | 69 | 1 |
| MRI FINDINGS (56 patients) | ||||
| Normal (%) | 30 | 7 | 48 | <0.001 |
| Cerebellar/pons atrophy (%) | 44 | 71 | 21 | <0.001 |
| Putaminal abnormalities (%) | 14 | 15 | 14 | 1 |
| Other (%) | 12 | 7 | 17 | 0.42 |