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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Psychol Med. 2014 Mar 24;44(13):2775–2786. doi: 10.1017/S0033291714000609

Table 2.

Demonstration of significant group differences in FA between FHP (n=48) and FHN (n=46) youth (21 voxels; p’s>0.001) in 19 white matter clustersa

Cluster Anatomical region Volume, μl MNI coordinatesb
FHN FA: mean (S.D.) FHP FA: mean (S.D.) Effect sizec
x y z
1 L inferior longitudinal fasciculusd 57 −46.1 −16.4 −19.6 0.47 (0.05) 0.51 (0.06) 0.76
2 Body of corpus callosumd,e 51 −15.0 13.0 29.7 0.54 (0.04) 0.57 (0.05) 0.72
3 L superior longitudinal fasciculusd,e 48 −35.2 −1.3 33.1 0.35 (0.04) 0.39 (0.04) 0.92
4 L sagittal stratumd,f 41 −38.1 −9.2 −17.2 0.44 (0.04) 0.47 (0.03) 0.88
5 R anterior limb of internal capsuled,e 41 19.6 18.9 1.3 0.42 (0.04) 0.45 (0.04) 0.88
6 R anterior thalamic radiationd,e 38 8.8 −15.0 9.4 0.27 (0.02) 0.28 (0.02) 0.86
7 R superior longitudinal fasciculusd,f 36 51.8 −28.4 −12.1 0.40 (0.04) 0.44 (0.04) 0.94
8 R superior longitudinal fasciculusd,e 35 39.9 −11.6 28.9 0.53 (0.05) 0.57 (0.04) 0.81
9 L inferior longitudinal fasciculusd,e 34 −47.0 −33.3 −10.2 0.49 (0.04) 0.52 (0.04) 0.87
10 R superior longitudinal fasciculusd,e 29 28.2 −9.0 44.0 0.41 (0.04) 0.45 (0.04) 0.84
11 L posterior corona radiatad 28 −26.0 −24.4 25.8 0.55 (0.03) 0.58 (0.04) 0.64
12 L inferior longitudinal fasciculusd,e 24 −32.7 −80.4 −4.9 0.32 (0.04) 0.36 (0.05) 0.81
13 L superior longitudinal fasciculusd 24 −42.3 −40.9 7.8 0.53 (0.04) 0.56 (0.04) 0.79
14 L forceps majord,f 24 −15.0 −73.2 15.0 0.25 (0.04) 0.29 (0.05) 0.92
15 R inferior longitudinal fasciculusd 22 55.1 −19.3 −15.7 0.28 (0.05) 0.31 (0.05) 0.78
16 Body of corpus callosumd 22 −12.8 −4.4 32.4 0.66 (0.04) 0.69 (0.04) 0.83
17 R external capsuled,e 21 30.7 −15.1 12.5 0.49 (0.03) 0.51 (0.03) 0.79
18 R forceps minord,f 21 20.5 42.7 19.2 0.47 (0.05) 0.51 (0.05) 0.71
19 L superior longitudinal fasciculusd,f 21 −43.0 −8.4 25.6 0.45 (0.04) 0.48 (0.05) 0.72

FA, Fractional anisotropy; FHP, family history positive; FHN; family history negative; MNI, Montreal Neurological Institute; S.D., standard deviation; L, left; R, right; MD, mean diffusivity; RD, radial diffusivity; AD, axial diffusivity.

a

In all regions, FHP youth showed higher FA than FHN teens. Regions are listed in order by largest to smallest volume.

b

Coordinates of the center of mass.

c

Cohen’s d effect sizes computed from means and S.D.s.

d

Within this region, there was lower RD in FHP compared with FHN youth (note: no regions showed higher RD in FHP group compared with FHN); p’s<0.01.

e

Within this region, there was lower MD in FHP compared with FHN youth (note: no regions showed higher MD in FHP group compared with FHN); p’s<0.05.

f

Within this region, there was higher AD in FHP compared with FHN youth (note: no regions showed lower AD in FHP group compared with FHN); p’s<0.02.