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Genetic characteristics of the various cell lines used in this study
| Cell Line | Microsatellite Status | Key Affected Genes | Key Restored Genes |
|---|---|---|---|
| HCT116 | MSI-H | ACVR2, TGFBR2, hMLH1 | |
| HCT116 + chr3 | MSS | ACVR2 | TGFBR2, hMLH1 |
| HCT116 + chr2 | MSI-H | TGFBR2, hMLH1 | ACVR2 |
| SW480 | MSS | SMAD4 |
MSI-H, high microsatellite instability; MSS, microsatellite stable; ACVR2, activin receptor 2; TGFBR2, transforming growth factor (TGF)-β receptor type 2; hMLH1, human mlh homolog 1.
