Table 2.
Neutralization of HIV-1 tier 1 and 2 isolates by members of CD4BS bnAb CH31 clonal lineage.
| TCID50, ug/ml |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| HIV-1 isolates |
Control | ||||||||
| Antibody | B.MN.3 | C.MW965 | B.SF162 | B.W61D | C.C3347 | C.DU172 | A.Q23 | A.TRO.11 | MuLV |
| UCA | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| 2FNGT3 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 | >50 |
| 2JSKAU | >50 | >50 | >50 | >50 | >50 | >50 | 1.51 | >50 | >50 |
| 2GNM7S | 30.1 | >50 | >50 | >50 | >50 | >50 | 6.57 | >50 | >50 |
|
| |||||||||
| 2H162G | 0.03 | 6.78 | 1.07 | 2.62 | 10.4 | 5.61 | 0.08 | 0.94 | >50 |
| 2H4SHE | <0.023 | 2.45 | 0.402 | 0.023 | 3.86 | 1.63 | 0.085 | 0.75 | >50 |
| 2G9LMX | <0.023 | 1.43 | 0.443 | 0.326 | 6.48 | 7.7 | 0.07 | 0.95 | >50 |
| I1 | 3.86 | 10.2 | 1.34 | >50 | 0.98 | 0.91 | <0.23 | 0.46 | >50 |
| I2 | 7.19 | 15.8 | 1.68 | >50 | 0.77 | 1.03 | <0.23 | 0.54 | >50 |
| I3 | 5.55 | 9.09 | 1.12 | >50 | 0.46 | 0.71 | <0.23 | 0.47 | >50 |
| I4 | 2.26 | 5.38 | 0.77 | >50 | 0.34 | 0.61 | <0.23 | 0.33 | >50 |
| CH31 | 0.0225 | 0.993 | 0.121 | 8.34 | 0.17 | 1.15 | <023 | 0.15 | >50 |
|
| |||||||||
| 2H162G − D1 | >50 | >50 | >50 | >50 | >50 | >50 | 3.19 | >50 | >50 |
|
| |||||||||
| 2GNM7S+D.1 | 14.3 | >50 | 49.7 | 38.3 | >50 | >50 | 4.21 | >50 | >50 |
| 2GNM7S+D2 | 16.2 | >50 | 27.4 | 5.8 | >50 | >50 | 25.0 | >50 | >50 |