. Author manuscript; available in PMC: 2014 Oct 14.

Published in final edited form as: J Parkinsons Dis. 2011;1(3):277–286. doi: 10.3233/JPD-2011-11046

Table 4.

LB densities and their age-adjusted association to duration of PD and nigral neuronal density

Brain region	Mean ± SD LB density (count per mm²) (range)	Duration of PD^*		Nigral neuronal density^*
Brain region	Mean ± SD LB density (count per mm²) (range)	ERR (95% CI)	p value	ERR (95% CI)	p value
Parietal cortex	0.1 ± 0.3 (0–2.4)	0.97 (0.91–1.04)	0.39	0.93 (0.83–1.05)	0.26
Frontal cortex	0.3 ± 0.8 (0–4.6)	0.95 (0.90–1.00)	0.05	1.02 (0.91–1.14)	0.67
Temporal cortex	0.7 ± 2.0 (0–13.5)	0.91 (0.86–0.96)	<0.001	0.90 (0.90–1.09)	0.87
Cingulate gyrus	1.4 ± 2.2 (0–13.3)	0.97 (0.93–1.00)	0.08	0.99 (0.94–1.05)	0.81
Entorhinal cortex	1.6 ± 2.7 (0–18.6)	0.93 (0.90–0.97)	<0.001	1.02 (0.96–1.09)	0.53
Total cortex	0.7 ± 1.2 (0–6.6)	0.95 (0.91–0.98)	0.005	1.00 (0.94–1.06)	0.94
Substantia nigra	1.8 ± 1.6 (0.1–9.3)	0.94 (0.92–0.96)	<0.001	1.10 (1.05–1.15)	<0.001

Multivariable model adjusted for age at death. CI = confidence interval; ERR = estimated relative rate; LB=Lewy body; PD = Parkinson’s disease; SD = standard deviation.