Table 1. CYP2D6 allele frequencies in Brazil.
| Allele frequency % (Number of chromosomes) | |||||
| CYP2D6 allele | Total sample | North | Northeast | Southeast | South |
| *1 | 39.9 (814) | 40.3 (198) | 36.8 (192) | 40.7 (210) | 41.9 (214) |
| *2 | 21.5 (438) | 24.4 (120) | 24.1 (126) | 18.8 (97) | 18.6 (95) |
| *3 | 0.7 (14) | 0.6 (3) | 0.8 (4) | 0.6 (3) | 0.8 (4) |
| *4 | 9.4 (191) | 10.8 (53) | 9.6 (50) | 7.7 (40) | 9.4 (48) |
| *5 | 4.6 (94) | 2.7 (13) | 5.4 (28) | 5.4 (28) | 4.9 (25) |
| *9 | 1.1 (23) | 1.0 (5) | 0.9 (5) | 1.3 (7) | 1.2 (6) |
| *10 | 2.05 (42) | 1.4 (7) | 1.7 (9) | 3.1 (16) | 1.9 (10) |
| *17 | 5.6 (114) | 5.3 (26) | 4.4 (23) | 7.4 (38) | 5.3 (27) |
| *29 | 3.4 (69) | 2.2 (11) | 2.3 (12) | 4.3 (22) | 4.7 (24) |
| *34 | 0.05 (1) | - | 0.2 (1) | - | - |
| *35 | 2.6 (53) | 2.2 (11) | 3.1 (16) | 2.9 (15) | 2.2 (11) |
| *39 | 0.8 (17) | 1.4 (7) | 0.4 (2) | - | 1.6 (8) |
| *41 | 5.5 (112) | 4.1 (20) | 7.8 (41) | 5.0 (26) | 4.9 (25) |
| *1×2 | 0.55 (12) | 0.8 (4) | 0.6 (3) | 0.6 (3) | 0.4 (2) |
| *1×3 | 0.05 (1) | 0.2 (1) | - | - | - |
| *2×2 | 0.55 (11) | 0.6 (3) | 0.4 (2) | 0.8 (4) | 0.4 (2) |
| *2×5 | 0.05 (1) | - | 0.2 (1) | - | |
| *4×2 | 0.2 (4) | 0.4 (2) | - | 0.4 (2) | - |
| *17×2 | 0.05 (1) | - | - | - | 0.2 (1) |
| *35×2 | 0.05 (1) | - | 0.2 (1) | - | - |
| Othersa | 1.3 (27) | 1.6 (8) | 1.1 (6) | 1.0 (5) | 1.6 (8) |
| Total number of chromosomes | 2040 | 492 | 522 | 516 | 510 |
a
SNP combination that could not be assigned to a known allele, for more information see Table S3.
χ2 = 70.184 and p-value = 0.069 for the comparison of the allele frequencies among the four regions.