Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1977 Jun;16(3):861–866. doi: 10.1128/iai.16.3.861-866.1977

Preparation of arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls.

O Kohashi, C M Pearson, Y Watanabe, S Kotani
PMCID: PMC421042  PMID: 302240

Abstract

Cell wall lytic enzyme (Kyowa lytic no. 2 enzyme) liberated arthritogenic hydrosoluble peptidoglycans from both arthritogenic and non-arthritogenic bacterial cell walls. From these cell walls, mutanolysin (peptidoglycan-degrading enzyme) also liberated hydrosoluble peptidoglycans which, however, lacked arthritogenicity. Based on the chemical composition of these peptidoglycans, it was suggested that their arthritis-inducing ability depends on a relatively long chain of glycan units that consists of repeated units of N-acetylglucosaminyl-N-acetylmuramic acid. However, the glycan chain lengths on these peptidoglycans appeared to be related to their adjuvancy rather than to an antigen(s) responsible for development of arthritis in rats.

Full text

PDF
861

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bacon P. A., Bluestone R., Goldberg L. S., Webb F. W., Pearson C. M., Cooke M., Stevens J. G. Experimental herpes virus arthritis. Factors in chronicity. Ann Rheum Dis. 1974 Sep;33(5):413–421. doi: 10.1136/ard.33.5.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bekierkunst A., Yarkoni E., Flechner I., Morecki S., Vilkas E., Lederer E. Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions. Infect Immun. 1971 Sep;4(3):256–263. doi: 10.1128/iai.4.3.256-263.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FLAX M. H., WAKSMAN B. H. Delayed cutaneous reactions in the rat. J Immunol. 1962 Oct;89:496–504. [PubMed] [Google Scholar]
  4. HASH J. H. PURIFICATION AND PROPERTIES OF STAPHYLOLYTIC ENZYMES FROM CHALAROPSIS SP. Arch Biochem Biophys. 1963 Sep;102:379–388. doi: 10.1016/0003-9861(63)90245-5. [DOI] [PubMed] [Google Scholar]
  5. Haley T. J., Farmer J., Jaques W. E., Frith C., Sprowls R. W., Schieferstein G. Dose-response hyperplasia and neoplasia from feeding N-2-fluorenylacetamide (2-FAA) to BALB/c mice for varying time intervals. Proc Soc Exp Biol Med. 1976 Jun;152(2):156–159. doi: 10.3181/00379727-152-39350. [DOI] [PubMed] [Google Scholar]
  6. Hamada S., Narita T., Kotani S., Kato K. Studies on cell walls of group A Streptococcus pyogenes, type 12. II. Pyrogenic and related biological activities of the higher molecular weight fraction of an enzymatic digest of the cell walls. Biken J. 1971 Sep;14(3):217–231. [PubMed] [Google Scholar]
  7. Kato K., Strominger J. L., Kotani S. Structure of the cell wall of Corynebacterium diphtheriae. I. Mechanism of hydrolysis by the L-3 enzyme and the structure of the peptide. Biochemistry. 1968 Aug;7(8):2762–2773. doi: 10.1021/bi00848a010. [DOI] [PubMed] [Google Scholar]
  8. Kato K., Strominger J. L. Structure of the cell wall of Staphylococcus aureaus. IX. Mechanism of hydrolysis by the L11 enzyme. Biochemistry. 1968 Aug;7(8):2745–2761. [PubMed] [Google Scholar]
  9. Keitel W., Wille R., Franke A., Ziegeler J. Adjuvant arthritis in mice and hamsters. Acta Rheumatol Scand. 1971;17(1):31–34. doi: 10.3109/rhe1.1971.17.issue-1-4.05. [DOI] [PubMed] [Google Scholar]
  10. Koga T., Kotani S., Narita T., Pearson C. M. Induction of adjuvant arthritis in the rat by various bacterial cell walls and their water-soluble components. Int Arch Allergy Appl Immunol. 1976;51(2):206–213. doi: 10.1159/000231593. [DOI] [PubMed] [Google Scholar]
  11. Koga T., Pearson C. M. Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D. J Immunol. 1973 Aug;111(2):599–608. [PubMed] [Google Scholar]
  12. Koga T., Pearson C. M., Narita T., Kotani S. Polyarthritis induced in the rat with cell walls from several bacteria and two Streptomyces species. Proc Soc Exp Biol Med. 1973 Jul;143(3):824–827. doi: 10.3181/00379727-143-37421. [DOI] [PubMed] [Google Scholar]
  13. Kohashi O., Pearson C. M., Shimono T., Kotani S. Preparation of various fractions from Mycobacterium smegmatis, their arthritogenicity and their preventive effect on adjuvant disease. Int Arch Allergy Appl Immunol. 1976;51(4):451–461. doi: 10.1159/000231619. [DOI] [PubMed] [Google Scholar]
  14. Kohashi O., Pearson C. M., Watanabe Y., Kotani S., Koga T. Structural requirements for arthritogenicity of peptidoglycans from Staphylococcus aureus and Lactobacillus plant arum and analogous synthetic compounds. J Immunol. 1976 Jun;116(6):1635–1639. [PubMed] [Google Scholar]
  15. Kotani S., Narita T., Stewart-Tull D. E., Shimono T., Watanabe Y. Immunoadjuvant activities of cell walls and their water-soluble fractions prepared from various gram-positive bacteria. Biken J. 1975 Jun;18(2):77–92. [PubMed] [Google Scholar]
  16. Lucherini T., Porzio F. Studi sulla provocazione di un'artrite sperimentale nel rhesus. Risultati conclusivi. Minerva Med. 1966 May 23;57(41):1851–1856. [PubMed] [Google Scholar]
  17. Schleifer K. H., Kandler O. Peptidoglycan types of bacterial cell walls and their taxonomic implications. Bacteriol Rev. 1972 Dec;36(4):407–477. doi: 10.1128/br.36.4.407-477.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stewart-Tull D. E., Shimono T., Kotani S., Kato M., Ogawa Y., Yamamura Y., Koga T., Pearson C. M. The adjuvant activity of a non-toxic, water-soluble glycopeptide present in large quantities in the culture filtrate of Mycobacterium tuberculosis strain DT. Immunology. 1975 Jul;29(1):1–15. [PMC free article] [PubMed] [Google Scholar]
  19. Thomas L. Experimental mycoplasma infections as models of rheumatoid arthritis. Fed Proc. 1973 Feb;32(2):143–146. [PubMed] [Google Scholar]
  20. Whitehouse M. W., Orr K. J., Beck F. W., Pearson C. M. Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. Immunology. 1974 Aug;27(2):311–330. [PMC free article] [PubMed] [Google Scholar]
  21. Wood F. D., Pearson C. M., Tanaka A. Capacity of mycobacterial wax D and its subfractions to induce adjuvant arthritis in rats. Int Arch Allergy Appl Immunol. 1969;35(5):456–467. doi: 10.1159/000230198. [DOI] [PubMed] [Google Scholar]
  22. Yokogawa K., Kawata S., Nishimura S., Ikeda Y., Yoshimura Y. Mutanolysin, bacteriolytic agent for cariogenic Streptococci: partial purification and properties. Antimicrob Agents Chemother. 1974 Aug;6(2):156–165. doi: 10.1128/aac.6.2.156. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES