. Author manuscript; available in PMC: 2014 Nov 18.

Published in final edited form as: Neurobiol Dis. 2014 Jan 14;65:188–192. doi: 10.1016/j.nbd.2013.12.017

Table 1.

Body mass and basal circulating glucose, insulin, and leptin concentrations in obese mouse models.

Mouse model	Genotype	Body mass (g)	Glucose (mg/dl)	Insulin (ng/mL)	Leptin (ng/mL)
+/+	+/+	28.9 ± 0.5	127.0 ± 8.5	0.53 ± 0.20	0.6 ± 0.3
ob/ob	ob/ob	54.9 ± 2.5^***	251.8 ± 56.6	10.69 ± 2.14^**	n.d.
db/db	db/db	49.7 ± 0.9^***	258.4 ± 62.6	17.41 ± 2.27^***	48.5 ± 4.4^***
Ay	+/+	27.2 ± 0.8	95.4 ± 5.5	0.74 ± 0.05	1.8 ± 0.7
	Ay/+	33.5 ± 1.4^**	132.8 ± 6.7^**	4.31 ± 0.40^***	36.3 ± 0.7^***
HFD	Control fed	26.6 ± 1.2	122.8 ± 14.8	0.72 ± 0.10	2.3 ± 0.2
	HFD fed	35.6 ± 0.3^***	155.5 ± 22.4	1.96 ± 0.37^*	35.8 ± 0.4^***
ΔGly-APN	ΔGly-APN +/+	21.3 ± 0.7	154.2 ± 7.3	1.44 ± 0.80	0.4 ± 0.1
	ΔGly-APN ob/ob	43.5 ± 3.0^***	212.3 ± 18.7^*	6.58 ± 0.88^**	n.d.

Data are presented as mean ± SEM. n.d. indicates value was not detectable.

Indicates P < 0.05 for obese vs. lean control (n = 5–10).

^**

Indicates P < 0.01 for obese vs. lean control (n = 5–10).

^***

Indicates P < 0.001 for obese vs. lean control (n = 5–10).