. Author manuscript; available in PMC: 2014 Nov 19.

Published in final edited form as: Nature. 2014 Jan 22;506(7487):179–184. doi: 10.1038/nature12929

Extended Data Table 1b.

Ratios of NS:S and LoF:missense de novo mutations were compared (Fisher’s exact test) between schizophrenia probands with poor scholastic performance and 1) controls; 2) probands with high scholastic performance. Nominally significant results (p<0.05) are marked in bold.

	Controls^7-10,13-14	Probands with poor scholastic performance (school grades 3 or 4)	Probands with high scholastic performance (school grades 5 or 6)
NS	434	222	242
S	155	67	84
Ratio	2.8	3.3	2.9

p vs. poor scholastic performance	0.32	-	0.51

LoF	49	40	23
missense	376	177	214
Ratio	0.13	0.23	0.11

p vs. poor scholastic performance	0.021	-	0.0095