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. 2014 Oct 3;35(12):2740–2747. doi: 10.1093/carcin/bgu207

Fig. 1.

Fig. 1.

Regional association plots for genotyped SNPs at the CDKN2A (left) and TP53 (right) gene loci. The top-ranked SNP at each locus is shown as a solid purple circle. SNPs are ordered by genomic location. The color scheme indicates LD between the top-ranked SNP and other SNPs in the region using r 2 values calculated from the 1000 Genomes Project. The y axis shows −log10 (P) values computed from 2515 EA cases and 3207 controls. Dashed red lines indicate the threshold for (nominal) statistical significance (P < 0.05). Available SNP annotations are depicted as follows: square (untranslated region), triangle (nonsynonymous), circle (none).