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. Author manuscript; available in PMC: 2014 Dec 4.
Published in final edited form as: Acta Neuropathol. 2013 Dec 24;127(1):29–51. doi: 10.1007/s00401-013-1230-6

Table 1.

Neuropathological findings in acute concussive injury compared to age-matched controls

ID Sport Age Race Sex Cause of death Conc Recent conc TAI Micro Astro PV
Mac		 PVCI PHF-tau Micro Bleed TDP43 Ab CAA aSYN Other
1 HS FB, BS KB 17 C M SIS 3 27D, 6D, 1D 4C 4C 4C 3C 0 I 0 1C 0 0 0 Subdural hematoma,
subarachnoid hem-
orrhage
2 HS FB 17 C M Suicide 2 2D 3C 3C 4C 2C 0 0 0 0 0 0 0 Small Cavum
3 HS RG, FB 18 C M Cerebral edema 4 19D, 6D 4C 3C 4C 3C 3C I 0 1C 0 0 0
4 FB,WR 14 C M Suicide 6 21D, 15D , 10D 1C 2C 2C 0 1C 0 0 0 0 0 0 Large cavum
5 Snow, HS FB 17 C M Suicide 10 126D 1C 3C 3C 2C 0 F 1C 0 0 0 0
6 HCK 28 C M Overdose >20 153D 3C 2C 2C 3C 0 II 0 2C 0 1C 0 Mammillary body
gliotic
7 HS FB 17 C M Overdose 1or 2 >3 YR 0 0 0 1C 0 0 0 0 0 0 0
9 HS FB 19 C M Cardiac 0 0 0 0 0 0 0 0 0 0 0 0 0
10 None 21 C M Suicide 0 0 0 1C 0 1C 1C 0 0 0 0 0 0
11 HS FB 22 C M Suicide 5 >7 YR 0 0 0 1C 0 0 0 0 0 0 0
12 HS FB 22 C M Seizure 6 >1 YR 0 0 0 3C 2C 0 0 0 0 0 0

I Stage I CTE, II Stage II CTE, aSYN alpha synuclein, A-beta amyloid plaques, Micro activated microglia, Astro astrocytosis, BSBK basketball, C Caucasian, CAA cerebral amyloid angiopathy, Conc concussion, D day, F focal, FB football, HCK ice hockey, HS high school, M male, PHF-TAU hyperphosphorylated tau, PV CI perivascular chronic inflammation, PV Mac perivascular macrophages, RG rugby, SIS second-impact syndrome, Snow snowboarding, TAI traumatic axonal injury, WR wrestling, YR year