Table 2.
Determination of Frailty
| Cutoff Points of Each Criterion | Number of Criteria Below the Cutoff Point in Each Mouse | ||
|---|---|---|---|
| Primary (1.5 SD below the mean) |
≥3 | 2 | None |
| Degree of frailty | Frail | Mildly frail | Nonfrail |
Notes: The performance of each mouse is tested across the four criteria (described in Table 1) and designated a score for each criterion. For each criterion, a cutoff point, at 1.5 SD below the mean, was set to define frailty. A mouse was identified as frail if three or more of the criteria measures were below the cutoff point, whereas, mild frailty was designated if two fell below the cutoff.