Table 1.
Relationship between covariates and maternal thyroid peroxidase antibody positivity (TPO-Ab+) in comparison subjects (N=960).
| TPO-Ab status1 | |||
|---|---|---|---|
| Positive | Negative | P2,3 | |
| Maternal age, Mean (SD) | 29.62 (4.65) | 29.22 (5.30) | 0.67 |
| Paternal age, Mean, (SD) | 33.21 (7.56) | 31.58 (5.98) | 0.22 |
| Previous births, N (%)4 | 0.60 | ||
| 0 | 16 (3.90) | 394 (96.10) | |
| ≥1 | 18 (3.27) | 532 (96.73) | |
| Maternal socioeconomic status5, N (%) | 0.95 | ||
| Upper white collar | 5 (4.17) | 115 (95.83) | |
| Lower white collar | 11 (3.18) | 335 (96.82) | |
| Blue collar | 5 (3.14) | 154 (96.86) | |
| Other6 | 5 (3.68) | 131 (96.32) | |
| Preterm birth, N (%)7 | 0.41 | ||
| <37 weeks | 0 (0) | 47 (100) | |
| ≥37 weeks | 34 (3.72) | 879 (96.28) | |
| Low birthweight, N (%)8 | 0.23 | ||
| <2500 g | 2 (7.69) | 24 (92.31) | |
| ≥2500 g | 32 (3.43) | 902 (96.57) | |
| Weight for gestational age, N (%)7,9 | 0.57 | ||
| SGA | 2 (7.14) | 26 (92.86) | |
| AGA | 31 (3.42) | 876 (96.58) | |
| LGA | 1 (4.00) | 24 (96.00) | |
| Family history, N (%) | |||
| Any maternal psychiatric disorder | 0.66 | ||
| Yes | 2 (4.65) | 41 (95.35) | |
| No | 32 (3.49) | 885 (96.51) | |
| Any parental psychiatric disorder | 0.79 | ||
| Yes | 3 (2.75) | 106 (97.25) | |
| No | 31 (3.64) | 820 (96.36) | |
| Gestational week blood draw, Mean (SD) | 11.03 (3.14) | 10.82 (3.38) | 0.73 |
Percentages expressed as row percents.
P values for maternal age, paternal age, and gestational week calculated by T-test; P values for previous birth, maternal socioeconomic status, preterm birth, low birthweight, weight for gestational age, and family history were calculated using Chi-square test
P values for categorical variables calculated by Fisher’s exact test except where indicated
Frequency missing: N= 6
Frequency missing: N=199
Includes individuals both within and outside the documented labor force (housewives, unemployed, students, retired, and self employed entrepreneurs).
Frequency missing: N=6
Frequency missing: N=4
SGA = Small for gestational age (< 2 SD); AGA = Average for gestational age (−2 SD to +2 SD); LGA = Large for gestational age (>2 SD). Calculated according to national sex-specific Finnish weight distribution standards at a given gestational age(61).