. Author manuscript; available in PMC: 2016 Mar 3.

Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 29;57:86–92. doi: 10.1016/j.pnpbp.2014.10.010

Table 3.

Maternal thyroid peroxidase antibody positivity (TPO-Ab+) and childhood autism¹

	Cases		Comparison Subjects

	TPO-Ab+		TPO-Ab +
	N	%	N	%	OR	95% CI	P
All subjects²
(N=960 matched case-comparison subject pairs)	59	6.15	34	3.54	1.78	1.16–2.75	0.009

By Sex

Males
(N=759 matched case-comparison subject pairs)	49	6.46	28	3.69	1.81	1.12–2.92	0.015
Females
(N=201 matched case-comparison subject pairs)	10	4.98	6	2.99	1.67	0.61–4.59	0.32

By co-morbid intellectual disability³

With intellectual disability
(N=273 matched case-comparison subject pairs)	17	6.23	15	5.49	1.13	0.57–2.27	0.72
Without intellectual disability
(N=687 matched case-comparison subject pairs)	42	6.11	19	2.77	2.35	1.33–4.15	0.003

The findings are unadjusted given that no covariate was associated with both TPO-Ab and autism

Results of adjusted analysis

ICD 10/9 codes for intellectual disability are as follows: F70/317 (mild), F71/318.0 (moderate), F72/318.1 (severe), F73/318.2 (profound), F78 (no ICD-9 code) (other), and F79/319 (unspecified).