Table 1.
SPM results for the differences between placebo (PL) and alcohol (ALC)a
| Region | BA | MNI coordinates, mm |
PL > ALC (NS) |
PL > ALC (VS) |
||||
|---|---|---|---|---|---|---|---|---|
| x | y | z | HD | NML | HD | NML | ||
| Calcarine | 17 | −8 | −82 | 0 | 7.2 | 3.7 | 5.6 | 2.3 |
| Calcarine | 17 | 12 | −70 | 6 | 7.0 | 3.4 | 4.9 | 2.2 |
| Cerebellum | −40 | −64 | −40 | 6.8 | 3.8 | 4.1 | 2.6 | |
| Cerebellum | −22 | −78 | −36 | 6.6 | 3.4 | 4.0 | 2.9 | |
| Vermis | 6 | −70 | −36 | 6.6 | 3.1 | 4.2 | 2.4 | |
| Superior occipital | 18 | −20 | −90 | 22 | 6.3 | 3.0 | 4.1 | NSb |
| Cerebellum | 36 | −72 | −22 | 6.1 | 3.8 | 5.3 | 2.2 | |
| Fusiform | 37 | 30 | −54 | −18 | 6.1 | 3.3 | 4.8 | 2.7 |
| Middle occipital | 19 | −40 | −84 | 0 | 6.0 | 3.1 | 4.4 | 1.9 |
| Inferior frontal | 44 | −48 | 10 | 24 | 5.7 | 2.5 | 3.9 | 1.6 |
| Superior orbitofrontal | 11 | −18 | 38 | −22 | 5.6 | 2.5 | 4.1 | 2.2 |
| Middle frontal | 47 | −38 | 46 | 0 | 5.4 | 2.2 | 3.3 | 1.8 |
| Inferior temporal | 20 | −52 | −10 | −26 | 5.3 | 2.1 | 3.8 | NSb |
| Inferior temporal | 20 | 64 | −44 | −14 | 5.3 | 3.0 | 3.7 | 2.2 |
| Middle cingulum | 23 | 2 | −38 | 34 | 5.2 | 2.7 | 3.5 | 1.7 |
| Middle occipital | 39 | 48 | −74 | 24 | 5.2 | 2.6 | 3.7 | 1.9 |
| Middle orbitofrontal | 11 | 30 | 42 | −16 | 5.2 | 2.8 | 4.6 | 2.0 |
| Inferior frontal | 45 | 52 | 30 | 4 | 5.2 | 2.6 | 3.4 | 2.0 |
| Superior temporal | 41 | −42 | −28 | 8 | 5.1 | 2.0 | 4.3 | NSb |
| Supramarginal | 42 | −58 | −24 | 18 | 5.1 | 1.7 | 3.3 | NSb |
| Superior frontal | 10 | −24 | 58 | 2 | 5.1 | 2.0 | 3.3 | 1.7 |
| Angular | 7 | 38 | −74 | 40 | 5.1 | 2.8 | 3.5 | 2.4 |
| Inferior frontal | 6 | 56 | 10 | 10 | 5.1 | 2.6 | 2.9 | 2.1 |
| Superior frontal | 10 | 24 | 56 | 14 | 5.1 | 2.4 | 3.2 | 1.9 |
| Angular | 39 | −50 | −62 | 24 | 5.1 | 2.1 | 3.8 | 1.7 |
| Superior temporal | 22 | 52 | −24 | 8 | 5.1 | 2.6 | 3.6 | 1.9 |
| Inferior temporal | 20 | 58 | −30 | −24 | 5.1 | 3.1 | 3.5 | 2.5 |
| Precentral | 44 | 48 | 6 | 34 | 5.0 | 2.7 | 3.7 | 2.0 |
| Superior temporal | 42 | −54 | −42 | 18 | 5.0 | 2.2 | 3.2 | NSb |
| Middle frontal | 9 | −30 | 40 | 36 | 5.0 | NS | 2.5 | NSb |
| Inferior parietal | 3 | −52 | −26 | 50 | 4.7 | 1.9 | 2.4 | NSb |
| Precentral | 6 | −36 | 2 | 56 | 4.7 | 2.0 | 3.0 | NSb |
| Middle cingulum | 32 | 8 | 36 | 30 | 4.5 | 2.0 | 2.6 | NSb |
| Middle frontal | 8 | −24 | 12 | 56 | 4.4 | 1.9 | 2.9 | NSb |
| Precentral | 6 | 38 | −8 | 56 | 4.3 | 1.7 | 2.6 | NSb |
| Thalamus | 0 | 14 | −18 | 8 | 4.3 | NS | 2.7 | NSb |
aData represent statistical significance (t-score) and the spatial location of the clusters showing significant differences in absolute glucose metabolism between placebo (PL) and alcohol (ALC) conditions under VS and NS for HDs and NMLs.
bNS, Not significant.