. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Clin Gastroenterol Hepatol. 2014 Aug 24;13(4):673–682. doi: 10.1016/j.cgh.2014.08.027

Table 3. Multivariable analysis of associations between combinations, ratios, and free (unbound) sex steroid hormones and Barrett's esophagus.

Variable	Controls (n=212)	Cases (n=173)	OR	95% CI	p value
Parent Estrogens (pmol/L)
<175.89	49	35
175.89-<220.52	51	52	1.16	(0.58, 2.31)	0.67
220.52-<280.81	47	49	1.74	(0.85, 3.55)	0.13
>280.81	50	23	0.62	(0.29, 1.36)	0.23
continuous	197	159	0.73	(0.39, 1.35)	0.31
Testosterone: Parent Estrogens Ratio (pmol/L)
<46.71	49	28
46.71-<69.53	51	61	2.27	(1.11, 4.64)	0.02
69.53-<89.55	50	43	1.79	(0.83, 3.87)	0.14
>89.55	47	26	2.02	(0.86, 4.77)	0.11
continuous	197	158	1.56	(0.86, 2.83)	0.14
Androstenedione: E1 Ratio (pmol/L)
<17.81	51	51
17.81-<22.84	48	41	0.81	(0.41, 1.60)	0.55
22.84-<30.43	51	33	0.77	(0.38, 1.55)	0.46
>30.43	47	34	1.32	(0.62, 2.82)	0.47
continuous	197	159	1.13	(0.65, 1.94)	0.67
Testosterone: E2 Ratio (pmol/L)
<119.31	50	30
119.31-<160.81	49	59	1.53	(0.76, 3.09)	0.23
160.81-<205.73	50	36	1.22	(0.56, 2.64)	0.61
>205.73	48	33	1.59	(0.71, 3.54)	0.26
continuous	197	158	1.27	(0.67, 2.43)	0.47
Free Testosterone (nmol/L)
<0.24	48	39
0.24-<0.29	50	35	1.50	(0.73, 3.11)	0.27
0.29-<0.38	51	48	2.77	(1.30, 5.87)	0.01
>0.38	48	35	5.36	(2.21, 13.03)	0.0002
continuous	197	157	2.67	(1.41, 5.08)	0.003
Free DHT (pmol/L)
<21.21	49	39
21.21-<27.13	49	37	1.28	(0.63, 2.60)	0.50
27.13-<35.44	49	37	1.98	(0.93, 4.23)	0.08
>35.44	50	44	4.25	(1.87, 9.66)	0.001
continuous	197	157	1.98	(1.16, 3.38)	0.01
Free Estradiol (pmol/L)
<1.96	50	40
1.96-<2.42	49	46	1.35	(0.68, 2.68)	0.40
2.42-<3.09	50	45	1.38	(0.69, 2.74)	0.36
>3.09	48	27	1.25	(0.58, 2.70)	0.56
continuous	197	158	1.28	(0.68, 2.41)	0.44

Adjusted for age, smoking status, alcohol consumption, heartburn, regurgitation, gastroesophageal symptom score (excluding heartburn and regurgitation), BMI, and race. Continuous sex steroid hormone values were standardized to half of the difference between the 75th and 25th centiles of the distribution.