Table 6. Comparison of AUCs for discriminating hepatic fibrosis stage in the whole cohort (N = 104).
| Parameters | Discrimination | Cut-off | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC (95% CI) | P-value after Bonferroni correction |
|---|---|---|---|---|---|---|---|---|
| F1 vs F2/3/4 | 83 ng/mL | 90.0 | 100 | 100 | 82.9 | 0.997 (0.965–1.000) | ||
| Osteopontin | F1/2 vs F3/4 | 124 ng/mL | 95.2 | 100 | 100 | 96.9 | 0.999 (0.965–1.000) | |
| F1/2/3 vs F4 | 152 ng/mL | 100 | 84.5 | 60.6 | 100 | 0.945 (0.879–0.979) | ||
| F1 vs F2/3/4 | 169×106/mL | 75.7 | 88.2 | 93.0 | 63.8 | 0.827 (0.740–0.894) | 0.0004* | |
| Platelet count | F1/2 vs F3/4 | 156×106/mL | 78.6 | 72.6 | 66.0 | 83.3 | 0.802 (0.708–0.870) | < 0.0001 # |
| F1/2/3 vs F4 | 135×106/mL | 85.0 | 75.0 | 44.7 | 95.5 | 0.861 (0.784–0.924) | 0.288 @ | |
| F1 vs F2/3/4 | 138 ng/mL | 48.6 | 91.2 | 91.9 | 46.3 | 0.763 (0.666–0.838) | < 0.0001* | |
| Hyaluronic acid | F1/2 vs F3/4 | 179 ng/mL | 59.5 | 88.7 | 78.1 | 76.4 | 0.794 (0.708–0.870) | < 0.0001 # |
| F1/2/3 vs F4 | 179 ng/mL | 90.0 | 83.3 | 56.3 | 97.2 | 0.886 (0.807–0.939) | 0.623 @ | |
| F1 vs F2/3/4 | 131 ng/mL | 84.3 | 55.9 | 79.7 | 63.3 | 0.747 (0.656–0.830) | < 0.0001* | |
| Collagen type IV | F1/2 vs F3/4 | 165 ng/mL | 66.7 | 77.4 | 66.7 | 77.4 | 0.783 (0.687–0.854) | < 0.0001 # |
| F1/2/3 vs F4 | 166 ng/mL | 80.0 | 70.2 | 39.0 | 93.7 | 0.822 (0.730–0.886) | 0.113 @ |
The AUC of serum OPN was compared with the AUCs of other serum markers.
F, fibrosis; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the receiver operating characteristic curve; CI, confidence interval
(*, F1 vs F2/F3/F4
#, F1/F2 vs F3/F4
@, F1/F2/F3 vs F4)