Table 2.
Ten consistently deregulated genes and their regulating miRNAs in ovarian cancers
| Genes | Gene ID | Alteration | Description | Effect | Regulating miRNAs |
Associated References |
|---|---|---|---|---|---|---|
| CLU | 1191 | clusterin | chemoresistance, prognosis |
70, 71 | ||
| ID4 | 3400 | down | inhibitor of DNA binding 4, dominant negative helix- loop-helix protein |
oncogenesis | miR-203 | 72 |
| BCAT1 | 586 | branched chain amino-acid transaminase 1, cytosolic |
chemo-resistance, oncogenesis |
let-7, miR-125b, miR-155 |
36, 73 | |
| FN1 | 2335 | fibronectin 1 | chemoresistance, prognosis |
74 | ||
| MAL | 4118 | mal, T-cell differentiation protein |
chemoresistance, prognosis |
31–32 | ||
| SERPINE1 | 5054 | up | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
invasion and metastasis |
miR-152 | 33 |
| SERPINA5 | 5104 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 |
putative tumor suppressor |
75 | ||
| SOX17 | 64321 | SRY (sex determining region Y)-box 17 |
||||
| TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa |
chemoresistance | 73 | ||
| THBS2 | 7058 | thrombospondin 2 |
metastasis | 33 |