Skip to main content
. 2015 Mar 9;125(4):1752–1762. doi: 10.1172/JCI78941

Figure 7. Increased frequency of circulating MAIT cells after bariatric surgery.

Figure 7

(A) Obese patients’ BMI before (pre-op; n = 62) and at 3, 6, and 12 months after surgery (post-op; n = 46, 47, and 39, respectively). †P < 0.0001. (B) HbA1c levels of obese patients with T2D before surgery (n = 19) and at 3, 6, and 12 months after surgery (n = 11, 12, and 9, respectively). **P = 0.003, ***P = 0.0005. (C and D) Circulating leptin and adiponectin levels in obese patients before (n = 52) and at 3, 6, and 12 months after surgery (n = 44, 46, and 39, respectively). †P < 0.0001. (E) Circulating MAIT cells frequency before (n = 69) and at 3, 6, and 12 months after surgery (n = 35, 34, and 35, respectively). (Control individuals, n = 23.) *P = 0.01, ***P < 0.002, †P < 0.0001. Circulating MAIT cell frequency was significantly lower in obese patients at each time point compared to control individuals (P < 0.05). (F) Cytokine production after PMA-ionomycin stimulation of MAIT cells from healthy individuals (n = 20) and obese patients before surgery (n = 39) and 3, 6, and 12 months after surgery (n = 38, 33, and 31, respectively). *P < 0.04, **P < 0.004, ***P = 0.0008, †P < 0.0001. Mann-Whitney U or Wilcoxon test.