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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Schizophr Res. 2014 Oct 25;167(0):84–90. doi: 10.1016/j.schres.2014.10.011

Table 1. Radioligand studies of GABAR binding in schizophrenia and schizoaffective disorder.

Study # SZ M/F SZ Age #HC M/F HC Age Subject type1 Med status Ligand Analysis Results
Busatto et al, 1997; Ball et al, 1998 14/1 29 11/1 28 yr Mixed Mixed IMZ ROI Group comparison n.s.; L med temp neg corr w/pos Sx; MFC neg corr w/neg Sx ; OC pos corr w/GAF; 10 ROIs have many pos corr w/cognitive measures and a few neg corr w/in SZ but not HC2
Schroder et al, 1997 20 30 yr -- -- Chronic Med IMZ ROI MFC pos corr w/BPRS total before DZP; after DZP: MFC, TPC, OC neg corr w/outcome2
Verhoeff et al, 1999 25/0 41 yr 24 37 yr Chronic Mixed IMZ WB Relative binding SZ<HC in L BA6, (t) in R BA9/44; n.s. correlations for PANSS
Abi-Dargham et al, 1999 16/0 44 yr 16/0 45 yr Chronic Med IMZ ROI/WB Group comparison n.s.; n.s. w/BPRS total or subscales
Asai et al, 2008 6/5 33 yr 12/0 29 yr Mixed Mixed Ro15 ROI Group comparison n.s; PFC neg corr w/PANSS negative, general, total; HIPP neg corr w/PANSS neg2
Lee et al, 2013 8/9 29 yr 9/9 26 yr Chronic Med FMZ WB SZ<HC in BA25, L BA38; HC<SZ in BA192
1

Acute = average duration of illness < 3 years; Chronic = average duration of illness ≥ 3 years

2

Corrections for multiple comparisons not done

Abbreviations: SZ, Schizophrenia/schizoaffective subjects; HC, healthy control subjects; M, male; F, female; Med, medicated; Unmed, unmedicated; IMZ, [123I]iomazenil; Ro15, [11C]Ro15-4513;FMZ, [18F]fluoroflumazenil; ROI, region of interest; WB, whole brain voxel-wise; n.s., no significant differences/correlations; neg corr w/, negative correlation with; pos corr w/, positive correlation with; (t), trend; pos Sx, positive symptoms; neg Sx, negative symptoms; L med temp, left medial temporal; MFC, medial frontal cortex; BPRS, Brief Psychiatric Rating Scale; DZP, diazepam; TPC, temporo-parietal cortex; OC, occipital cortex; GAF, Global Assessment of Functioning; BA, Brodman Area; PANSS, positive and negative syndrome scale; PFC, prefrontal cortex; HIPP, hippocampus;