Table 2.
Family-based and combined (case-control and family-based) association results. Family-based association P-values were computed using the empirical variance estimator implemented in the FBAT software package (8). Combined Fisher P-values for all case-control (Table 1) and nuclear family cohorts are also shown (8). UTR, untranslated region.
| Marker | Location | Non-Jewish CD (518 families, 651 affected offspring) | Non-Jewish UC (215 families, 251 affected offspring) | Jewish CD (77 families, 99 affected offspring) | Jewish UC (80 families, 91 affected offspring) | All IBD (883 families, 1,119 affected offspring) | Combined (family-based and case-control) P-value |
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| P-value | P-value | P-value | P-value | P-value | |||
| rs1004819 | Intron | 3.60 × 10−5 | 1.20 × 10−3 | 1.24 × 10−2 | 5.47 × 10−1 | 6.06 × 10−8 | 1.78 × 10−14 |
| rs7517847 | Intron | 2.30 × 10−5 | 2.71 × 10−1 | 3.50 × 10−2 | 5.00 × 10−1 | 1.80 × 10−5 | 9.99 × 10−16 |
| rs10489629 | Intron | 1.87 × 10−3 | 2.70 × 10−1 | 4.33 × 10−1 | 8.21 × 10−1 | 1.27 × 10−3 | 1.62 × 10−11 |
| rs2201841 | Intron | 5.80 × 10−4 | 3.21 × 10−4 | 3.50 × 10−2 | 5.69 × 10−1 | 1.04 × 10−7 | 1.10 × 10−14 |
| rs11465804 | Intron | 1.32 × 10−4 | 2.70 × 10−3 | 8.90 × 10−5 | 3.71 × 10−1 | 3.46 × 10−9 | 3.33 × 10−16 |
| rs11209026 | Arg381Gln | 8.00 × 10−6 | 2.97 × 10−4 | 9.41 × 10−4 | 4.91 × 10−1 | 1.32 × 10−10 | 6.62 × 10−19 |
| rs1343151 | Intron | 9.63 × 10−2 | 8.51 × 10−2 | 3.30 × 10−2 | 1.89 × 10−1 | 1.24 × 10−3 | 2.74 × 10−12 |
| rs10889677 | Exon-3′UTR | 2.60 × 10−3 | 3.35 × 10−4 | 5.88 × 10−2 | 7.32 × 10−1 | 1.65 × 10−6 | 3.40 × 10−14 |
| rs11209032 | Intergenic | 2.68 × 10−3 | 3.57 × 10−4 | 3.48 × 10−2 | 7.50 × 10−1 | 2.41 × 10−6 | 5.50 × 10−13 |
| rs1495965 | Intergenic | 4.07 × 10−4 | 1.74 × 10−2 | 3.93 × 10−2 | 9.21 × 10−1 | 1.72 × 10−5 | 3.55 × 10−9 |