Table E3.
List of cytokine genes regulated by PGD2, LTE4, or their combination in TH2 cells detected by means of PCR array∗
| Upregulation |
Downregulation |
||||||
|---|---|---|---|---|---|---|---|
| Gene | Sample treatment |
Gene | Sample treatment |
||||
| PGD2 | LTE4 | PGD2 + LTE4 | PGD2 | LTE4 | PGD2 + LTE4 | ||
| IL3 | + | ++ | +++ | BMP4 | − | − | − |
| IL5 | ++ | ++ | +++ | BMP8B | − | − | − |
| IL8 | ++ | + | +++ | GDF9 | − | − | − |
| IL9 | + | + | +++ | IFNA5 | − | − | − |
| IL10 | + | + | ++ | IFNK | − − | − | − |
| IL13 | + | + | ++ | IL15 | − | − | − |
| IL21 | + | ++ | +++ | IL17C | − | − | − |
| IL22 | + | ++ | +++ | IL18 | − | − | − |
| CSF1 | + | + | ++ | IL24 | − | − | − |
| CSF2 | ++ | ++ | +++ | NODAL | − − | − | − |
| FASLG | ++ | + | ++ | TGFB3 | − | − | − |
| LTA | + | + | ++ | TNFSF13B | − − | − | − − |
| PDGFA | ++ | + | ++ | ||||
| TNF | + | + | + | ||||
| TNFSF8 | + | + | ++ | ||||
| TNFSF10 | + | + | + | ||||
| TNFSF11 | ++ | + | ++ | ||||
| TNFSF14 | + | + | + | ||||
CSF, Macrophage colony-stimulating factor.
++ or − −, Fold change of 3 or greater; +++, fold change of 6 or greater.
∗
Concentrations of PGD2 and LTE4 were 100 and 50 nmol/L, respectively.