Figure 7.
Gene expression in response to LPD in G59S mice. (A) mRNA levels of genes involved in macro-autophagy (LC3, p62, FoxO3 and Beclin1) in the spinal cord of wild-type (black) and G59S-mice (grey) fed with chow diet (−) or low protein diet (LPD, +). (B and C) mRNA (B) and protein (C) levels of Lamp2-A in the spinal cord of wild-type (black) and G59S-mice (grey) fed with chow diet (−) or low protein diet (LPD, +). (D) mRNA levels of genes involved in lysosomal biogenesis (Lamp1, Cathepsin B, Cathepsin D and ATP6v1h) in the spinal cord of wild-type (black) and G59S-mice (grey) fed with chow diet (−) or low protein diet (LPD, +).