TABLE 1.
NAD+ Consuming Enzymes
| Enzyme | Km Value (μM) | References |
|---|---|---|
| SIRT1 | 94-96 | (Gerhart-Hines et al., 2011; Pacholec et al., 2010) |
| SIRT2 | 83 | (Borra et al., 2004) |
| SIRT3 | 880 | (Hirschey et al., 2011) |
| SIRT4 | 35 | (Laurent et al., 2013) |
| SIRT5 | 980 | (Fischer et al., 2012) |
| SIRT6 | 26 | (Pan et al., 2011) |
| SIRT7 | Unknown | |
| PARP1 | 50-97 | (Amé et al., 1999; Jiang et al., 2010; Mendoza-Alvarez and Alvarez-Gonzalez, 1993) |
| PARP2 | 130 | (Amé et al., 1999) |
| PARP4 (VPARP) | Unknown | |
| Tankyrase 1 (PARP5a) | 1125-1500 | (Jiang et al., 2010; Rippmann et al., 2002) |
| Tankyrase 2 (PARP5b) | Unknown | |
| CD38 | 15-25 | (Cakir-Kiefer et al., 2001; Fulco et al., 2008; Sauve et al., 1998) |
*
Only poly-ADP-Ribosylating PARPs were included in this table.