|
Median age (interquartile ranges)
|
62.7 (53.9–71.1) |
63.6 (54.4–71.9) |
|
Age range (years)
|
7.3–98.9 |
8.1–100.3 |
|
Sex, n (%)
|
|
|
| Female |
19,249 (43.2) |
52,471 (43.6) |
| Male |
25,348 (56.8) |
67,902 (56.4) |
|
Calendar year at index date, n (%)
|
|
|
| 1999–2003 |
10,019 (22.5) |
43,982 (36.5) |
| 2004–2008 |
26,090 (58.5) |
37,463 (31.1) |
| 2009–2013 |
8,488 (19.0) |
38,928 (32.4) |
|
Alcohol use at study entry, n (%)
|
|
|
| No |
6,487 (14.6) |
21,302 (17.7) |
| Yes |
30,633 (68.7) |
77,281 (64.2) |
| Former |
3,431 (7.7) |
7,511 (6.2) |
| Excessive |
2,378 (5.3) |
7,135 (5.9) |
| Unknown |
1,668 (3.7) |
7,144 (5.9) |
|
Smoking at study entry, n (%)
|
|
|
| Current |
7,403 (16.6) |
22,411 (18.6) |
| Former smoker |
22,483 (50.4) |
56,041 (46.6) |
| Never |
14,083 (31.6) |
40,085 (33.3) |
| Unknown |
628 (1.4) |
1,836 (4.5) |
|
BMI (kg/m
2
) at study entry, n (%)
|
|
|
| <18.5 |
130 (0.3) |
577 (0.5) |
| 18.5–24.9 |
5,352 (12.0) |
18,422 (15.3) |
| 25.0–29.9 |
14,578 (32.7) |
40,933 (34.0) |
| ≥30 |
23,727 (53.2) |
56,188 (46.7) |
| Unknown |
810 (1.8) |
4,253 (3.5) |
|
Treatment stage, n (%)
|
|
|
| First-line monotherapy |
942 (2.1) |
4,317 (3.6) |
| Second-line monotherapy |
1,768 (4.0) |
3,182 (2.6) |
| Second-line combination |
41,887 (93.9) |
112,874 (93.7) |
|
Comorbidities, n (%)
|
|
|
|
Head injury
|
1,457 (3.3) |
3,885 (3.2) |
|
Diabetes duration
|
|
|
| 0–2 years before entry study |
8,979 (20.1) |
32,146 (26.7) |
| 2–5 years before entry study |
12,631 (28.3) |
28,584 (23.7) |
| 5–9 years before entry study |
12,308 (27.6) |
28,827 (23.9) |
| >9 years before entry study |
10,595 (23.8) |
30,438 (25.3) |
| Diabetes diagnosis missing |
84 (0.2) |
378 (0.3) |
|
HbA
1c
levels
|
|
|
| <7.5% (<57 mmol/mol) |
8,419 (18.9) |
37,912 (31.5) |
| 7.6%–8.3% (>57 mmol/mol and <66 mmol/mol) |
11,810 (26.5) |
26,505 (22.0) |
| 8.4%–9.6% (>66 mmol/mol and <80 mmol/mol) |
12,444 (27.9) |
25,005 (20.8) |
| >9.6% |
11,751 (26.3) |
28,966 (24.1) |
| HbA1c missing |
173 (0.4) |
1,985 (1.6) |
|
Comedications, n (%)
|
|
|
|
Calcium channel blockers (CCB)
|
|
|
| Never |
28,115 (63.0) |
78,397 (65.1) |
| Past user: Used >6 months before index date |
6,811 (15.3) |
23,287 (19.4) |
| Current user for <1 year |
1,182 (2.7) |
3,376 (2.8) |
| Current user for >1 year |
8,489 (19.0) |
15,313 (12.7) |
|
Hormone replacement therapy (HRT)
|
|
|
| Never |
39,516 (88.6) |
109,578 (91.0) |
| Past user: Used >6 months before index date |
4,200 (9.4) |
8,834 (7.3) |
| Current user for <1 year |
67 (0.2) |
324 (0.3) |
| Current user for >1 year |
814 (1.8) |
1,637 (1.4) |
