Figure 4.
Effects of lubiprostone on gut microbiota in uremic mice. (A) Unweighted unifrac distance analysis (upper panel) and diversity of bacterial species as indicated by Chao1 rarefaction measure (lower panel) of gut microbiota in the control, RF, and RF+Lub500 groups. n=6. (B) Relative abundance of microbiota on the basis of the average number of each subfamily at the order, family, and genus levels. The major subfamilies are indicated on the right. n=6. Cont, control. (C) The proportional change of each subfamily at the genus level. Genera displaying a significant change among the three groups are shown (Steel–Dwass). The y axis indicates the abundance of each microbe (percentage). C, control; RF+L, RF treated with 500 µg/kg per day lubiprostone. *P<0.05 versus the control group; §P<0.05 versus the RF group.