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. 2015 Aug 5;35(31):11125–11132. doi: 10.1523/JNEUROSCI.4615-14.2015

Figure 2.

Figure 2.

Synaptically induced LTD is impaired in Eif4ebp2−/− mice and unresponsive to group I mGluR antagonists. A, PP-LFS induced a stable LTD in wild-type mice, while it was completely absent in Eif4ebp2−/− mice. B, PP-LFS LTD was not affected by incubation with JNJ16259285 in wild-type mice. Similarly, the impairment in this form of LTD in Eif4ebp2−/− mice was not changed by the mGluR1 antagonist. C, The mGluR5 antagonist fenobam did not affect the response to PP-LFS in either wild-type or Eif4ebp2−/− mice. D, fEPSP slope at 70–80 min after PP-LFS onset for Eif4ebp2+/+ (n = 12), Eif4ebp2+/+ plus JNJ16259285 (n = 7), Eif4ebp2+/+ plus fenobam (n = 7), Eif4ebp2−/− (n = 10), Eif4ebp2−/− plus JNJ16259285 (n = 8), and Eif4ebp2−/− plus fenobam (n = 12). Insets in A–C are representative traces. Calibration: 50 ms and 0.5 mV. ***p < 0.001.