Figure 3.
LRRK2-G2019S enhances synaptic transmission through a postsynaptic mechanism. A, Sample mEPSC traces. The top trace shows currents from a control slice on an expanded time scale. Scale bars: top, 10 pA, 10 ms; middle and bottom, 10 pA, 5 s. B, C, mEPSC frequency (B) and amplitude (C) are unchanged in LRRK2-G2019S mice (n = 7 slices, 3 mice) compared with controls (n = 7 slices, 3 mice). D, The evoked AMPAR/NMDAR EPSC ratio in whole-cell patch is similar in LRRK2-G2019S (n = 11 slices, 7 mice) and control mice (n = 9 slices, 5 mice). Scale bars: top trace, 30 pA, 20 ms; bottom trace, 100 pA, 20 ms. E, The evoked AMPAR/NMDAR EPSC ratio using perforated patch is increased in LRRK2-G2019S (n = 11 slices, 6 mice) and control mice (n = 9 slices, 7 mice; p = 0.044). Scale bars: top trace, 5 pA, 20 ms; bottom trace, 5 pA, 20 ms.