Table 2.
Serum markers of liver function in control, CP, and CP rats pretreated with 18β-GA
| Parameter | Control | CP | CP + 25 mg GA | CP + 50 mg GA |
|---|---|---|---|---|
| ALT (U/L) | 23.58 ± 4.51 | 85.44 ± 9.77*** | 49.22 ± 5.78### | 33.26 ± 5.02###$$ |
| AST (U/L) | 39.48 ± 8.03 | 106.51 ± 10.72*** | 65.18 ± 11.31### | 45.31 ± 8.69###$ |
| ALP (U/L) | 60.11 ± 6.29 | 149.43 ± 13.42*** | 81.55 ± 10.58### | 72.19 ± 15.70### |
| γGT (U/L) | 11.68 ± 4.07 | 31.42 ± 5.16*** | 17.44 ± 3.89## | 14.73 ± 4.26### |
| LDH (U/L) | 241.19 ± 18.81 | 467.22 ± 29.71*** | 317.55 ± 18.93### | 246.02 ± 21.82###$$ |
| Albumin (g/dL) | 3.09 ± 0.63 | 1.97 ± 0.31* | 2.80 ± 0.42 | 3.11 ± 0.53# |
Data are M ± SD (N = 6)
ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, γGT gamma-glutamyl transferase, LDH lactate dehydrogenase, CP cyclophosphamide, GA glycyrrhetinic acid, SD standard deviation, vs versus
* P < 0.05 and *** P < 0.001 versus control, # P < 0.05, ## P < 0.01, and ### P < 0.001 versus CP, and $$ P < 0.01 versus CP + 25 mg GA group